Safety and Efficacy of 21 Gy, 23 Gy and 25 Gy for High Dose Rate (HDR) Prostate Brachytherapy
Recruiting now · Phase 1/Phase 2
Conditions studied: Prostate Cancer, Prostate Neoplasm
In brief
The purpose of this research study is to learn more about the outcomes and early and late side effects of treating early stage prostate cancer with high dose rate brachytherapy.
Key facts
- Study ID
- NCT03424850
- Run by
- Washington University School of Medicine
- People needed
- 36
- Starts
- 2018-02-27
- Expected to finish
- 2030-02-28
- Last updated by the study team
- 2026-03-11
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Histologically or cytologically confirmed diagnosis of early stage prostate cancer.
- Must be considered either low-risk (T1-T2a, Gleason ≤ 6, PSA < 10 ng/mL) or favorable intermediate-risk (Gleason 3 +4 = 7, percentage of positive biopsy cores < 50%, no more than one NCCN intermediate risk factor).
- Prior androgen deprivation therapy is allowed and may have been initiated up to 6 months prior to the date of the HDR implant. The complete duration of androgen deprivation therapy can range from 4 months to 36 months provided it has been initiated no more than 6 months prior to the date of the HDR implant.
- At least 18 years of age.
- ECOG performance status ≤ 2
- Able to understand and willing to sign an IRB approved written informed consent document (or that of legally authorized representative, if applicable).
You may not qualify if…
- Prior radiation therapy to the prostate or lower pelvis encompassing the prostate.
- A history of other malignancy ≤ 5 years previous with the exception of basal cell or squamous cell carcinoma of the skin which were treated with local resection only.
- Currently receiving any other investigational agents.
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, or cardiac arrhythmia.
- Unable to undergo general, spinal or local anesthesia.
- Prior TURP with a sufficiently large defect that would compromise the integrity of the implant per clinician's assessment.
Where it is running
- Washington University School of Medicine — St Louis, Missouri, United States (enrolling)
Full record on ClinicalTrials.gov
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