Pathophysiology of Inborn Immunodeficiencies

Recruiting now

Conditions studied: Primary Immune Deficiency Disorder

In brief

The pathophysiology of primary immunodeficiencies (PID), which encompass a broad range of different diseases with susceptibility to infection and/or a deregulated inflammatory response, is poorly understood. Available treatments are often not specific for a distinct target and might be associated with side effects. To elucidate pathophysiology of different PIDs, stool, urine, blood, tissue biopsies and/or bone marrow will be collected and analysed for anti-microbial activity and inflammatory response. In a second step, targeted treatment for different PIDs might be developed preclinically and ex vivo according to underlying pathophysiology.

Key facts

Study ID

NCT03422614

Run by

University of Zurich

People needed

300

Starts

2015-03-01

Expected to finish

2033-03-30

Last updated by the study team

2026-05-06

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Clinical diagnosis of an inborn error of immunity (primary immunodeficiency, PID)
• Clinically healthy (non-age matched) volunteer

You may not qualify if…

• exclusion of an inborn error of immunity
• secondary immunodeficiency
• refusal to enter the study

Where it is running

• University Children's Hospital Zurich — Zurich, Switzerland (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.