Energy Expenditure and Weight Loss Maintenance

Completed

Conditions studied: Obesity, Weight Change, Body, Weight Loss, Physical Activity

In brief

Obesity is reaching epidemic proportions and threatens both health and quality of life of people around the world. While many individuals succeed at short term weight loss, weight loss maintenance is the greatest barrier to successful treatment of obesity. High levels of physical activity are consistently associated with success in weight loss maintenance. The major goal of this proposal is to understand how and why high levels of physical activity are critical for long term maintenance of weight loss. This project takes advantage of the National Weight Control Registry (NWCR), which follows over 6000 individuals who have maintained a weight loss of ≥30 pounds for ≥1 year. Understanding how individuals successful at weight loss maintenance achieve energy balance will provide important insight into strategies to help more people sustain a weight loss.

Key facts

Study ID

NCT03422380

Run by

University of Colorado, Denver

People needed

112

Starts

2009-10-01

Expected to finish

2012-09-01

Last updated by the study team

2018-02-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men or women
• Age 18-65
• Weight stable (<10 lb fluctuation in body weight over previous 6 months) or
• NWCR subjects successful at weight loss maintenance (maintaining a loss of ≥ 30 pounds for at least 2 years)
• Non-Reduced Weight Matched Controls: Individuals matched to NWCR subjects' current body weight. These individuals will be normal weight (BMI 18-25, BMI up to 27 allowed in men with waist circumference < 40 cm), and have no history of overweight or obesity (BMI >25) and will not be maintaining a weight loss ≥ 30 pounds.
• Non-Reduced Obese Controls: Individuals matched to NWCR subjects' maximum pre-weight loss body weight. These individuals will be overweight or obese (BMI ≥ 26-45).

You may not qualify if…

• Diabetes
• Uncontrolled HTN (>160/100)
• History of cardiac disease: CHF or angina, atrial fibrillation or ventricular tachycardia, or significant abnormality on resting EKG
• Symptoms suggestive of cardiovascular disease: chest pain, shortness of breath at rest or with mild exertion, dizziness, syncope.
• History of neurological disease: stroke, TIA or seizure disorder
• Current treatment for cancer (except skin)
• Severe pulmonary, liver or kidney disease
• Untreated thyroid disorder
• Severe arthritis or other musculoskeletal disorder
• Alcohol or drug abuse
• Active psychiatric illness
• Positive response to PAR-Q indicating requirement for monitored physical activity
• Other serious medical condition as determined by the investigator which would limit physical activity or require monitored activity.
• Pregnant and lactating women, and women actively trying to become pregnant (post-menopausal women on a stable dose of HRT and pre-menopausal women on a stable OCP regimen will be allowed to participate)
• Smoking within the past 6 months
• Subjects using prescription or over the counter medication which may affect RMR including beta blockers, stimulants such as Ritalin and appetite suppressants.
• Subjects who have undergone bariatric surgery or who are currently maintaining their weight loss with prescription weight loss drugs or supplements.
• Severe claustrophobia
• Moderate or high levels of physical activity at the workplace and unable to reduce workplace activity, work from home or take time off from work to participate in Study 2.
• We will exclude controls if they are weight reduced (maintaining a weight loss of ≥ 30 pounds).

Where it is running

• University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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