Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise

Completed · Not applicable

Conditions studied: Aging

In brief

Advanced age is the main risk factor for chronic diseases such as cardiovascular disease, type 2 diabetes, Alzheimer's disease and cancer. One reason may be due to decreased resistance to oxidative stress as antioxidant defenses and cell protection is reduced with aging. This has been shown in animal studies and also that the impairment can be somewhat restored with exercise. This will be the first study to test this in humans by comparing young and older inactive adults before and after an exercise intervention, a practical and cost-effective intervention that can have tremendous public health impact by lowering risk for disease and medical-related costs.

Key facts

Study ID

NCT03419988

Run by

Northern Arizona University

People needed

46

Starts

2017-06-01

Expected to finish

2020-06-30

Last updated by the study team

2020-08-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women, 18-28 years or 60 years and older
• Competent to independently give informed consent
• Successful completion of screening
• No regular exercise for the past 6-months (by self-report)
• A score below 3.0 on the Historical Lifetime Physical Activity Questionnaire

You may not qualify if…

• Estrogen supplementation within the previous 6 months
• Use of anti-oxidant supplements, in excess of standard multi-vitamins (1 tablet/day)
• Current smoker
• Body Mass Index (BMI) ≤33 kg/m2 (Class I Obesity)
• Any chronic illness that could affect outcome measures, including diabetes, liver or renal disease, or cancer (other than skin cancer)
• History of a myocardial infarction within the last 6 months, clinically significant aortic stenosis, use of cardiac defibrillator, or uncontrolled angina
• Clinically significant arrhythmia on a resting EKG or significant EKG changes during the baseline maximal oxygen consumption (VO2 max) test
• Any other condition that would contraindicate maximal exercise testing, including elevated blood pressure at rest (systolic BP >150 or diastolic BP >90 mm Hg on at least 2 measurements, at least 10 minutes apart) or musculoskeletal problems

Where it is running

• Northern Arizona University — Flagstaff, Arizona, United States

Full record on ClinicalTrials.gov

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