The Role of Opioidergic Systems in Breathing Based Analgesia

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Pain

In brief

The purpose of this psychophysical and pharmacologic study is to determine if slow-breathing induced pain relief is mediated by endogenous opioids in response to intravenous (IV) administration of the opioid antagonist naloxone during noxious heat stimulation. We were also interested in disentangling the endogenous analgesic mechanisms supporting mindfulness-based analgesia.

Key facts

Study ID

NCT03419858

Run by

University of California, San Diego

People needed

60

Starts

2017-03-13

Expected to finish

2017-06-27

Last updated by the study team

2019-06-11

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Normal volunteers with no history of chronic pain problems
• Volunteers had no prior meditation experience
• Volunteers could be male and non-pregnant females.
• Volunteers of all ethnic backgrounds were included.

You may not qualify if…

• Female volunteers could not be pregnant.
• They could not be taking opioids or antidepressants.
• Subjects with a repeated history of syncope, loss of consciousness, light headedness, nausea, dizziness, or vomiting in response to needles or blood could not participate in the study.
• Subject could not be using exogenous opiates for the complete duration of the study.

Where it is running

• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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