SMaRT Blood: Single-unit Versus Multiple-unit Packed Red Blood Cell Transfusion in Non-acute Postpartum Anemia

Completed · Not applicable

Conditions studied: Postpartum Anemia Nos

In brief

There is a paucity of data on management of non-acute postpartum anemia. Although blood transfusions were historically initiated with 2 units, the most recent recommendation from the American Association of Blood Banks is to begin with 1 unit. As no randomized controlled trials have been performed in obstetrics, the investigators propose a randomized, controlled trial in non-acute postpartum anemia comparing single- versus multiple-unit transfusion by total numbers of units transfused and maternal morbidity.

Key facts

Study ID

NCT03419780

Run by

University of Pennsylvania

People needed

66

Starts

2018-03-01

Expected to finish

2020-06-01

Last updated by the study team

2020-11-04

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women over 18
• Willing and stable to give consent
• > 6 hours postpartum from any mode of delivery
• Determined by their physician to require blood transfusion either by:
• Hb <7g/dL OR
• >7g/dL with any sign or symptom of anemia such as fatigue, dizziness, tachycardia, or hypotension
• Agreed to accept blood transfusion
• No contraindications to blood transfusion

You may not qualify if…

• hemoglobinopathies
• patients with an ejection fraction <35%
• Hb <5 g/dL
• HR > 130 bpm, BP < 80/40

Where it is running

• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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