Low Intensity Physical Activity During Sitting on Glycemic Control and Vascular Function in Obese Individuals
Completed · Not applicable
Conditions studied: Obesity, Metabolic Syndrome
In brief
Prolonged sitting is a common behavior in contemporary humans. In epidemiological studies, increased sitting time has been associated with increased risk for cardiovascular disease and all-cause mortality. Recent research has also shown that interrupting sitting time with standing prevents the poorer glycemic control. However, studies are lacking which evaluate the impact of low intensity physical activity during prolonged sitting on vascular function. Whether low intensity physical activity can increase blood flow substantially and prevent impairment in vascular function and glycemic control is unknown. The purpose of the present study is to evaluate whether increased blood flow during sitting via low intensity physical activity (fidgetting) prevents the impairment in vascular function and poorer glycemic control associated with prolonged sitting.
Key facts
- Study ID
- NCT03419754
- Run by
- University of Missouri-Columbia
- People needed
- 20
- Starts
- 2018-03-20
- Expected to finish
- 2020-03-01
- Last updated by the study team
- 2020-03-24
Who can join
Age: 20 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Obese males and females with metabolic syndrome, aged 20-60 years old.
- According to the NCEP ATP III definition, metabolic syndrome is present if three or more of the following five criteria are met:
- waist circumference over 40 inches (men) or 35 inches (women),
- blood pressure over 130/85 mmHg,
- fasting triglyceride (TG) level over 150 mg/dl,
- fasting high-density lipoprotein (HDL) level less than 40 mg/dl (men) or 50 mg/dl (women)
- fasting blood sugar over 100 mg/dl.
You may not qualify if…
- they smoke
- they have any known cardiovascular, pulmonary or metabolic disease
- have type 2 diabetes
- if good quality Doppler ultrasound image of their arteries cannot be obtained and/or evidence of plaque.
Where it is running
- University of Missouri — Columbia, Missouri, United States
Full record on ClinicalTrials.gov
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