Adipose Tissue Inflammation in Individuals Undergoing Bariatric Surgery

Completed

Conditions studied: Obesity, Morbid, Bariatric Surgery Candidate

In brief

A growing body of work done over the past few decades has established that adipose tissue as an active endocrine organ which secretes a wide range of metabolic and immunological factors collectively called "adipokines (1)." Importantly, these secreted factors enter into the circulation and have paracrine and autocrine actions, which profoundly impact systemic metabolism (e.g., insulin sensitivity). Additionally, in animals, loss of ovarian hormone production via ovariectomy (similar to menopause in humans) leads to increases in both in adipose tissue mass and in adipose tissue inflammation (2) making this tissue less healthy than that from premenopausal animals. To date, no studies have investigated the effect of menopause on abdominal fat in overweight individuals. Knowing if adipose tissue-specific changes occur with menopause may potentially lead to recommendations or therapeutics to improve women's health post menopause.

Key facts

Study ID

NCT03419273

Run by

University of Missouri-Columbia

People needed

84

Starts

2017-07-01

Expected to finish

2019-07-01

Last updated by the study team

2019-10-03

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Women who are premenopausal or who are postmenopausal and have been for at least one year.
• Males will be recruited to age match female subjects. All subject are already scheduled to have bariatric surgery at the University of Missouri-Columbia Department of Surgery.

You may not qualify if…

• Women who are perimenopausal. Women who are on Hormone Replacement Therapy.

Where it is running

• University of Missouri — Columbia, Missouri, United States

Full record on ClinicalTrials.gov

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