Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children

Recruiting now

Conditions studied: Seizures

In brief

Electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous EEG monitoring for seizure identification and management. When identified, electrographic seizures are generally treated with anti-seizure medications, but there are very limited data available regarding optimal treatment in terms of the efficacy or safety of specific anti-seizure medications or overall management strategies. This is a single-center prospective observational study. The investigators aim to: (1) track critically ill patients undergoing clinically indicated EEG monitoring and seizure management to identify risk factors for electrographic seizures, (2) create prediction models guiding EEG monitoring resources to the patients at highest risk for seizures, and (3) evaluate our current management strategy in terms of safety.

Key facts

Study ID

NCT03419260

Run by

Children's Hospital of Philadelphia

People needed

2500

Starts

2017-03-13

Expected to finish

2028-01-01

Last updated by the study team

2026-06-29

Who can join

Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Care in the Children's Hospital of Philadelphia Pediatric ICU.
• Clinically indicated continuous EEG monitoring.
• Age > 1 month to 18 years.

You may not qualify if…

• Admitted for Phase 2 (intracranial) EEG monitoring.
• Intensivist expects to discontinue technological support in the next two days given underlying medical or neurological problems.

Where it is running

• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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