Assessing Efficacy of Neuropsychiatric Assessment and Treatment Protocols in Huntington's Disease Patients
Completed · Not applicable
Conditions studied: Huntington Disease
In brief
Phase A: Recruit 50 patients with HD, and their caregivers, to complete a neuropsychiatric and quality of life battery of scales at baseline. Have these 50 patients complete a formal psychiatric assessment with a psychiatrist within 2 weeks of this clinical battery, and the results of these 2 types of assessments will be compared to establish the level of agreement between clinical rating scales and formal psychiatric assessment. Phase B: Continue to follow Phase A cohort longitudinally and administer neuropsychiatric and quality of life battery at 6 months, 12 months, and 18 months form baseline. Recruit an additional 50 patients, administer the same neuropsychiatric and quality of life battery at baseline, implement medication and counseling intervention according to a standard of care protocol, and follow up with the same neuropsychiatric and quality of life battery at 6, 12, and 18 months.
Key facts
- Study ID
- NCT03417583
- Run by
- Vanderbilt University Medical Center
- People needed
- 100
- Starts
- 2018-11-09
- Expected to finish
- 2023-10-10
- Last updated by the study team
- 2023-11-15
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient participants:
- Diagnosed with HD, either through genetic testing or neurologist's clinical diagnosis
- Patient has at least 1 neuropsychiatric symptom, as reported by their HD provider
- 21 and older will be included, as symptoms of Juvenile HD (in patients 20 years old or less) can present differently
- Presence of an eligible caregiver who can also participate in the study with them because several of the study measures require caregiver report
- Caregivers:
- 18 years or older
- A caregiver will be defined as someone who lives with or has at least weekly contact with the HD patient
You may not qualify if…
- Patient participants:
- 20 years old or younger
- Greater than moderate impairment on dementia screening
- Lack of a caregiver to provide collateral information and complete caregiver assessments will also be excluded
- Caregivers:
- Younger than 18 years old and/or have less than weekly contact with the HD patient
- Clinical impression of incompetency to answer survey questions as determined by the Jessie Sellers, Nurse Practitioner, or the neurologist caring for the HD patient, then he or she will not be eligible to participate.
Where it is running
- Vanderbilt Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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