Valchlor in the Treatment of Lichen Planopilaris

Completed · Phase 2

Conditions studied: Lichen Planopilaris

In brief

The primary objective of this study is to assess the potential effectiveness of once daily application of Valchlor in decreasing disease activity in patients with Lichen Planopilaris. The primary measurement of efficacy will be with the Lichen Planopilaris Activity Index (LPPAI) before and after 6 months of treatment. Secondary measures of efficacy will be the mean follicular density, Physician Global assessment (PGA) score, and the Dermatology Quality of Life Index (DQLI) score before and after six months of therapy.

Key facts

Study ID

NCT03417141

Run by

Mayo Clinic

People needed

12

Starts

2018-04-01

Expected to finish

2019-08-30

Last updated by the study team

2021-01-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female patients 18 years or older.
• Biopsy proven diagnosis of Lichen Planopilaris
• Biopsy proven diagnosis of Fontal Fibrosing Alopecia (a clinical variant of LPP restricted to frontal scalp)
• Good general health as confirmed by medical history
• Patients who are willing and capable of cooperating to the extent and degree required by the protocol; and
• Patients who read and sign an approved informed consent for this study

You may not qualify if…

• Vulnerable study population
• Pregnant or nursing women
• Women planning a pregnancy within the study period
• Active smokers
• Known history of adverse reaction to mechlorethamine
• Use of systemic immunosuppressive
• Presence of ulcerated scalp lesions

Where it is running

• Mayo Clinic in Florida — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

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