The Role of Cognitive Control in the Transdiagnostic Conceptualization of "Intrusive Thoughts"

Completed · Not applicable

Conditions studied: Obsessive-Compulsive Disorder, Generalized Anxiety Disorder, Major Depressive Disorder

In brief

The investigators are examining whether difficulties with cognitive control (i.e., the ability to stop one's thought process and shift attention) is a common problem across three types of repetitive, negative thinking: obsessions (as seen in obsessive compulsive disorder, OCD), worries (as seen in generalized anxiety disorder, GAD), and ruminations (as seen in major depressive disorder, MDD).

Key facts

Study ID

NCT03414619

Run by

Massachusetts General Hospital

People needed

75

Starts

2018-05-18

Expected to finish

2020-03-06

Last updated by the study team

2020-03-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults (age 18+)
• Intrusive thoughts group: Clinically significant intrusive thought in the domain of obsessions, worries, or depressive ruminations with a score above the clinical mean (≥ 37) on the trait repetitive negative thinking measure (Perseverative Thinking Questionnaire, PTQ)
• Non-psychiatric control (NPC) group: A score 1 SD below the community mean (≤ 15) on the trait repetitive negative thinking measure (PTQ)
• Sufficient fluency of English to understand study procedures and questionnaires
• Ability to provide informed consent.
• Comfortable and capable of using a computer and completing reaction-time tasks.

You may not qualify if…

• Acute psychosis, mania, or suicidality
• Diagnosis of post-traumatic stress disorder (PTSD; in order to preserve diagnostic clarity of the domains of intrusive thoughts under investigation)
• Serious neurological disorder or impairment (e.g., brain damage, blindness), attention deficit hyperactivity disorder (ADHD), intellectual disability, or autism.

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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