Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery

Completed · Early Phase 1

Conditions studied: Surgical Anesthesia, Cesarean Section

In brief

Regional anesthesia is commonly used for elective and emergency cesarean delivery. It provides numerous safety advantages when compared to general anesthesia for both the mother and fetus1. Epidurals also have the added benefit of being able to provide pain relief throughout labor and in the event of cesarean delivery, epidural analgesia can be "extended" to provide surgical anesthesia. Numerous studies have been performed to assess the onset times of various local anesthetics when administered through an epidural catheter. Attempts to reduce anesthetic onset time and improve the quality of intraoperative analgesia have been attempted by using different local anesthetic solutions and by the addition of other drugs to the epidural solution (such as epinephrine, fentanyl and sodium bicarbonate).

Key facts

Study ID: NCT03414359
Run by: University of Arkansas
People needed: 70
Starts: 2018-02-15
Expected to finish: 2019-03-27
Last updated by the study team: 2020-04-13

Who can join

Age: 18 and older, up to 99. Sex: female. Healthy volunteers: accepted.

You may qualify if…

≥ 18 years of age for the mother
Singleton pregnancy
Gestation > 36 weeks
American Society of Anesthesiologist (ASA) class II
Provides written consent
Infant of mother

You may not qualify if…

Patient refusal
Non-elective or urgent/emergent cesarean sections
ASA class III or above
Unable to understand English
Significant back surgery or scoliosis
Known fetal abnormality
Weight > 120 kg
Height < 150 cm
Allergy to local anesthetics
Concurrent use of sulfonamides

Where it is running

University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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