Brain Mechanisms Supporting Meditation-based Analgesia

Completed · Not applicable

Conditions studied: Pain

In brief

Mindfulness meditation has been shown to reduce pain in experimental and clinical settings, and the neural mechanisms underlying this analgesia are distinct from that of placebo related beliefs in the utility of the meditation. Although previous studies have identified potential cortical and sub-cortical targets responsible for mediating these effects, the connectional relationships between them remains largely unexplored. The present study will use blood-oxygen-level dependent (BOLD) neuroimaging to assess functional connections supporting mindfulness meditation.

Key facts

Study ID

NCT03414138

Run by

University of California, San Diego

People needed

40

Starts

2018-04-20

Expected to finish

2018-08-02

Last updated by the study team

2019-06-11

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Normal volunteers between ages 18 and 65.
• Men and women of all races will be included

You may not qualify if…

• Subjects with a history of psychiatric or neurological disorders.
• Subjects will be excluded if they report being claustrophobic.
• Subjects with a prior history of meditation training will be excluded.
• Subjects with ferrous metal or electronic devices (e g., pacemakers) implanted in there body will be excluded.
• Pregnant subjects will be excluded.
• Subjects that demonstrate no pain to noxious temperatures (>49°C) or excessive responses to temperatures at or below 43°C will be excluded.

Where it is running

• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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