Exercise and Weight Control
Completed · Not applicable
Conditions studied: Obesity, Exercise Reinforcement
In brief
The objective of this project is to determine the biological, neurobehavioral, and behavioral compensatory responses to exercise training-induced energy deficits in overweight to obese men and women. Participants will engage in exercise at either 2 days or 6 days per week for 12 weeks and have body composition assessed via DXA before and after the exercise intervention. Accumulated energy balance (weight loss converted to kcal) will be compared to exercise energy expenditure to determine each individual's level of compensation, termed compensation index. Predictors of compensation index that will be assessed will include hunger/satiety hormone concentrations at rest and in response to a meal, reward driven feeding, changes in metabolic rate, and energy intake throughout the intervention. Exercise reinforcement and physical activity will also be assessed as a separate aim to determine if exercise reinforcement can be increased and if this can promote greater habitual physical activity after the intervention has ceased.
Key facts
- Study ID
- NCT03413826
- Run by
- University of Kentucky
- People needed
- 80
- Starts
- 2018-01-04
- Expected to finish
- 2019-08-18
- Last updated by the study team
- 2019-12-13
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participants must be overweight to obese (BMI 25-35 kg/m2) Not pregnant or lactating or planning to become pregnant in the next 6 months
- No limitations to safely participating in physical activity
You may not qualify if…
- Currently dieting to lose weight and no weight loss or gain >2kg over the past 3 months,
- Taking any medications that affect energy expenditure or eating,
- Regularly exercising (planned and structured aerobic or resistance activity).
- Participants must have no major health problems, cannot have known cardiovascular (cardiac, peripheral vascular, cerebrovascular), pulmonary (COPD, interstitial lung disease, cystic fibrosis) or metabolic (diabetes, thyroid disorders, renal or liver disease) disease.
- Tobacco use
- Have a medical condition that prevents safe exercise.
Where it is running
- Funkhouser Building — Lexington, Kentucky, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.