Obesity and Adipose Tissue Inflammation in Pregnant Mothers

Completed

Conditions studied: Healthy

In brief

To date very little research has been conducted on pregnant mothers. Research shows that mothers with obesity and gestational diabetes have children who have a higher risk of later developing obesity and diabetes compared to children born to non-obese mothers but the mechanisms are not known. The maternal environment may place these babies at greater risk and it is possible that fat tissue (adipose tissue) releases many chemicals (adipokines and inflammatory cytokines) which may have an impact on the baby. Mothers who have greater amounts of adipose tissue most likely release these adipokines into the baby and it may affect the baby's body composition and/or health. This project will establish if there is a relationship between obesity and adipose tissue inflammation in pregnant mothers, and if there is a link between inflammation and the child's body composition. We will recruit mothers with low risk pregnancies already schedule for a C section at about 36 wk. We will do initial testing at 36 wk, adipose tissue collection at delivery, and conduct post testing at 1 month postpartum on the mother and the baby.

Key facts

Study ID

NCT03412981

Run by

University of Missouri-Columbia

People needed

27

Starts

2017-12-01

Expected to finish

2020-10-31

Last updated by the study team

2020-11-03

Who can join

Age: 21 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Mothers who have low risk pregnancies (21-40 years) and are already scheduled to have a C-section. BMI ≤ 40 kg/m2

You may not qualify if…

• We will exclude emergency C-sections
• Subjects will have had a screening ultrasound that demonstrated the absence of congenital anomalies as part of routine prenatal care
• Mothers with high risk pregnancy
• BMI > 40 kg/m2

Where it is running

• University of Misouri — Columbia, Missouri, United States
• University of Missouri — Columbia, Missouri, United States

Full record on ClinicalTrials.gov

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