Hyperbaric Oxygen Therapy in Sickle Cell Pain
Completed · Not applicable
Conditions studied: Vaso-occlusive Crisis, Sickle Cell Anemia Crisis
In brief
Sickle cell anemia is a genetic blood disorder where red blood cells are abnormally shaped, crescent- or sickle-shaped, instead of the normal, round shape. This misshapen cell is rigid and sticky, causing them to clump together and block small blood vessels. This blockage can lead to pain, infections, and organ damage, and the shortened lifespan of sickle cells causes anemia. The purpose of this study is to explore if hyperbaric oxygen (HBO) therapy would decrease pain and hospital length of stay associated with acute sickle cell pain crisis. Adults presenting with an uncomplicated acute pain crisis (i.e., acute chest syndrome, acute myocardial infarction/stroke) would be eligible. The intervention would be 1-3 hyperbaric oxygen sessions depending on response to therapy. Each treatment session will be approximately two hours in length. Evaluation would be through participants' self--assessment via the visual analog scale for pain level before and after treatments as well as tracking length of stay in the hospital.
Key facts
- Study ID
- NCT03412045
- Run by
- University of Nebraska
- People needed
- 8
- Starts
- 2022-09-01
- Expected to finish
- 2025-06-05
- Last updated by the study team
- 2026-07-28
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 19 years old or older
- Present with an uncomplicated sickle cell crisis at admission friom the emergency department
You may not qualify if…
- < 19 years old
- pregnant female
- complicated sickle cell crisis present (i.e., concomitant MI, stroke, acute chest syndrome at time of presentation)
Where it is running
- Unversity of Nebraska Medical Center — Omaha, Nebraska, United States
Full record on ClinicalTrials.gov
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