Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia
Completed · Phase 3
Conditions studied: Homozygous Familial Hypercholesterolemia
In brief
The primary objectives of the study are: * To evaluate the long-term safety and tolerability of evinacumab in patients with Homozygous Familial Hypercholesterolemia (HoFH) * To evaluate the long-term safety and tolerability of evinacumab in adolescent patients with HoFH The secondary objectives of the study are: * To evaluate the effect of evinacumab on lipid parameters in patients with HoFH * To evaluate the effect of evinacumab on lipid parameters in adolescent patients with HoFH * To evaluate the potential development of anti-evinacumab antibodies
Key facts
- Study ID
- NCT03409744
- Run by
- Regeneron Pharmaceuticals
- People needed
- 116
- Starts
- 2018-03-13
- Expected to finish
- 2023-04-13
- Last updated by the study team
- 2025-04-08
Who can join
Age: 12 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Clinical Trial Site — Los Angeles, California, United States
- Clinical Trial Site — Boca Raton, Florida, United States
- Clinical Trial Site — Boston, Massachusetts, United States
- Clinical Trial Site — New York, New York, United States
- Clinical Trial Site — Cincinnati, Ohio, United States
- Clinical Trial Site — Portland, Oregon, United States
- Clinical Trial Site — Philadelphia, Pennsylvania, United States
- Clinical Trial Site — Dallas, Texas, United States
- Clinical Trial Site — Dallas, Texas, United States
- Clinical Trial Site — Camperdown, New South Wales, Australia
- Clinical Trial Site — Perth, Western Australia, Australia
- Regeneron Study Site — Vienna, State of Vienna, Austria
- Regeneron Study Site — Innsbruck, Austria
- Clinical Trial Site — Chicoutimi, Quebec, Canada
- Clinical Trial Site — Québec, Canada
- Regeneron Study Site — Prague, Kateřinská, Czechia
- Clinical Trial Site — Paris, Cedex 13, France
- Clinical Trial Site — Marseille, Cedex 5, France
- Clinical Trial Site — Dijon, Cedex, France
- Regeneron Study Site — Kallithea, Athens, Greece
- Clinical Trial Site — Ioannina, Greece
- Clinical Trial Site — Naples, Campania, Italy
- Clinical Trial Site — Roma, Rome, Italy
- Clinical Trial Site — Ōbu, Aichi-ken, Japan
- Regeneron Study Site — Kurume, Fukuoka, Japan
Full record on ClinicalTrials.gov
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