Evaluating the Safety and Pharmacokinetics of PC-1005 Administered Rectally to HIV-1 Seronegative Adults

Completed · Phase 1

Conditions studied: HIV Infections

In brief

The purpose of this study is to evaluate the safety and pharmacokinetics of PC-1005 gel when used as a rectal microbicide in HIV-uninfected men and women (cis or transgender) with a history of consensual receptive anal intercourse.

Key facts

Study ID

NCT03408899

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

13

Starts

2018-06-19

Expected to finish

2019-04-19

Last updated by the study team

2023-04-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women (cis or transgender) who are 18 years or older at Screening, verified per site standard operating procedure (SOP)
• Able and willing to provide written informed consent
• HIV-1/2 uninfected at Screening and Enrollment, per applicable algorithm in the protocol and willing to receive HIV test results
• Able and willing to provide adequate locator information, as defined in site SOP
• Available to return for all study visits and willing to comply with study participation requirements
• In general good health at Screening and Enrollment, as determined by the site Investigator of Record (IoR) or designee
• At Screening, history of consensual receptive anal intercourse (RAI) at least once in their lifetime per participant report
• Willing to not take part in other research studies involving drugs, medical devices, genital or rectal products, or vaccines for the duration of study participation (including the time between Screening and Enrollment)
• Willing to follow abstinence requirements for the duration of study participation (See the protocol for additional information)
• For participants of childbearing potential: a negative pregnancy test at Screening and Enrollment
• For participants of childbearing potential: Per participant report at Enrollment, using an effective method of contraception and intending to use an effective method for the duration of study participation; these include:
• Hormonal methods, excluding vaginal rings
• Intrauterine device (IUD) inserted at least 42 days prior to Enrollment (but not past the maximum length of recommended usage according to package instructions)
• Sterilization of participant or partner at least 42 days prior to Enrollment
• Self-identifies as having sex with women exclusively

You may not qualify if…

• At Screening:
• Hemoglobin Grade 1 or higher*
• Platelet count Grade 1 or higher*
• White blood count Grade 2 or higher*
• Aspartate aminotransferase (AST) or alanine transaminase (ALT) Grade 1 or higher*
• Serum creatinine greater than 1.3x the site laboratory upper limit of normal (ULN)
• International normalized ratio (INR) greater than 1.5x the site laboratory ULN
• History of inflammatory bowel disease by participant report
• * As per the Division of AIDS Table for Grading the Severity of Adult and Pediatric Adverse Events Corrected Version 2.1, July 2017
• Note: Otherwise eligible participants with an exclusionary test result can be re-tested during the screening process. If a participant is re-tested and a non-exclusionary result is documented within 45 days of providing informed consent for screening, the participant may be enrolled.
• Known adverse reaction to latex or polyurethane (ever)
• Anticipated use of and/or unwillingness to abstain from the following medications during study participation:
• Anticoagulant medications
• Rectally-administered medications
• Known adverse reaction to any of the components of the study product
• Use of pre-exposure prophylaxis (PrEP) for HIV prevention within 1 month prior to Enrollment, and/or anticipated use and/or unwillingness to abstain from PrEP during trial participation
• Use of post-exposure prophylaxis (PEP) for potential HIV exposure within the 3 months prior to Enrollment
• Condomless RAI and/or penile-vaginal intercourse with a partner who is known to be HIV-positive or whose status is unknown in the 6 months prior to Enrollment
• Non-therapeutic injection drug use in the 12 months prior to Enrollment
• Participation in research studies involving drugs, medical devices, genital or rectal products, or vaccines within 30 days of the Enrollment Visit
• Gynecologic, genital, or rectal procedure (e.g., tubal ligation, dilation and curettage, piercing, hemorrhoidal resection, polyp removal) 60 days or less prior to Enrollment, or rectal biopsy, 7 days or less prior to Enrollment. Note: Colposcopy and cervical biopsies for evaluation of an abnormal Pap test as well as IUD insertion/removal are not exclusionary. Anoscopy and endoscopy without rectal biopsies are not exclusionary
• Per participant report, medical records, clinical diagnosis and/or diagnostic testing at either Screening or Enrollment:
• Diagnosis or treatment of any anogenital sexually transmitted infection (STI) in the past 3 months (including window between Screening and Enrollment)
• Symptoms, clinical or laboratory diagnosis of active pharyngeal, anorectal infection or reproductive tract infection (RTI) requiring treatment per current Centers for Disease Control and Prevention (CDC) guidelines (http://www.cdc.gov/std/treatment)
• Current symptomatic urinary tract infection (UTI)

Where it is running

• Alabama CRS — Birmingham, Alabama, United States
• University of Pittsburgh CRS — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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