A Dose-Escalation Study of MDX-010 Administered Monthly as Immunotherapy in Subjects Infected With Human Immunodeficiency Virus (HIV)

Completed · Phase 1

Conditions studied: Human Immunodeficiency Virus (HIV)

In brief

The purpose of this study is to assess the safety and tolerability of 2 or 4 doses of MDX-010 in HIV-infected subjects

Key facts

Study ID

NCT03407105

Run by

Bristol-Myers Squibb

People needed

24

Starts

2003-04-21

Expected to finish

2006-02-21

Last updated by the study team

2018-01-23

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Detectable HIV viremia (HIV-1 RNA level between 1,000 and 100,000 copies/mL)
• CD4 count greater than or equal to 100 cells/mm3
• Current antiretroviral therapy regimen following at least 2 previous changes for documented virologic failure
• Documented resistance tests demonstrating the presence of at least 1 mutation to each major therapeutic class of antiretroviral therapy
• No significant organ compromise

You may not qualify if…

• Initiation of any new medications that might reasonably affect the immune response or viral load within 4 weeks prior to screening
• Tetanus booster immunization within 2 months of screening, or a history of anaphylaxis or severe local reaction to the tetanus vaccine
• History of autoimmune disease at risk for recurrence
• Current malignancy, except Stage A or B cervical carcinoma or basal cell carcinoma
• Chronic viral hepatitis, due to Hepatitis B or Hepatitis C undergoing current treatment or Hepatitis B DNA greater than 25 pg/cc or Hepatitis C RNA greater than 20,000 IU/cc
• Currently undergoing treatment or prophylaxis for tuberculosis infection
• Chronic active infectious disease (other than HIV)

Where it is running

• Tower ID Medical Associates — Los Angeles, California, United States
• Quest Clinical Research — San Francisco, California, United States
• Care Resource — Miami, Florida, United States
• Orlando Immunology Center — Orlando, Florida, United States
• Shannon Schrader, MD — Houston, Texas, United States

Full record on ClinicalTrials.gov

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