Modulation of Episodic Memory Using Theta Burst Stimulation (TBS)

Withdrawn before enrolling · Not applicable

Conditions studied: Aging

In brief

The goal of this study is to evaluate the effect of white matter guided theta burst stimulation on episodic memory task performance in healthy older adults. The investigators aim to propagate the effect of theta burst stimulation from a superficial locus of stimulation (angular gyrus) to hippocampus and parahippocampal regions using white matter tract connection between these regions. Study activities and population group - for the study plans to recruit 20 healthy older adults who already have white matter scans acquired as part of another study performed by the Cabeza Lab at Duke University. Using tractography the exact site of stimulation on the cortical surface will be localized. An initial motor evoked potential (MEP) assessment will differentiate responders to theta burst stimulation from non responders. Responders will receive 1200 pulses of intermittent theta burst stimulation (iTBS) or sham stimulation to the angular gyrus while they perform the encoding portion of an episodic memory task. There after, they will perform retrieval piece of the task and data analysis will compare these performances.

Key facts

Study ID

NCT03406195

Run by

Duke University

People needed

0

Starts

2018-12-15

Expected to finish

2019-12-30

Last updated by the study team

2018-09-06

Who can join

Age: 60 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy controls in the age group 60-80 years old
• No other Diagnostic and Statistical Manual of Mental Disorders (DSM) 5 axis 1 diagnoses
• Willing to provide informed consent
• Structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) data available

You may not qualify if…

• Subjects are unable or unwilling to give informed consent
• Presence of any organic brain illness
• Presence or history of stroke, traumatic brain injury or head injury with loss of consciousness, transient ischemic attack (TIA), any diagnosed neurological disorder including but not limited to multiple sclerosis, Huntington's disease, Parkinson's disease, dementia or major neurocognitive disorder.
• Presence of cranial metal implants, structural brain lesion including but not limited to cerebral aneurysms.
• Presence of devices that may be affected by repetitive transcranial magnetic stimulation (rTMS) (pacemaker, medication pump, cochlear implant, implanted brain stimulator)
• Current or recent (within the past 6 months) substance abuse or dependence, excluding nicotine and caffeine.
• Current serious medical illness
• History of seizure except those therapeutically induced by electroconvulsive therapy (ECT) (childhood febrile seizures are acceptable and these subjects may be included in the study), history of epilepsy in self or first degree relatives
• For subjects age > 59 years, a total scaled score < 8 on the Dementia Rating Scale-2.

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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