Red Blood Cell ATP Release and Vascular Function in Humans
Completed · Phase 2 · Has a placebo group
Conditions studied: Cardiovascular Diseases
In brief
Previous work demonstrates that the red blood cells of older adults do not release a potent vasodilator (ATP) as well as the red blood cells of younger adults. The investigators are targeting a pathway within the red blood cell using fasudil hydrochloride to determine if both the release of ATP from red blood cells and blood flow responses to low oxygen (hypoxia) and exercise in older adults can be improved.
Key facts
- Study ID
- NCT03404843
- Run by
- Colorado State University
- People needed
- 31
- Starts
- 2017-07-14
- Expected to finish
- 2018-10-05
- Last updated by the study team
- 2020-02-27
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy
- Sedentary to moderately active
- 18 to 30 years old for young subjects
- 60 to 80 years old for older subjects
You may not qualify if…
- Obesity (BMI ≥ 30 kg/m\^2)
- Cardiovascular disease
- Metabolic disease
- Use of medications that can influence cardiovascular function
- Blood pressure greater than or equal to 140/90
- Smoker
- Use of hormone replacement therapy
Where it is running
- Colorado State University, Dept. of Health and Exercise Science — Fort Collins, Colorado, United States
Full record on ClinicalTrials.gov
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