Muscle Vibration in MS to Improve Walking

Stopped early · Not applicable

Conditions studied: Multiple Sclerosis

In brief

The primary goal of this pilot study is to explore the feasibility of cyclic vibration (CV) of the lower extremity muscles to improve walking in individuals with gait deficits from multiple sclerosis (MS).

Key facts

Study ID

NCT03403413

Run by

VA Office of Research and Development

People needed

5

Starts

2017-01-01

Expected to finish

2018-12-31

Last updated by the study team

2020-05-08

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• MS diagnosis reviewed and confirmed by neurologist per the revised McDonald criteria [ ]
• EDDS>3
• Age 18-70
• Fixed gait deficiency defined as being present for at least 3 months without improvement
• Hip, knee and ankle muscle weakness or increased extensor tone with difficulty to initiate a step
• Ability to ambulate at least 10ft with contact guard.
• Muscle vibration without untoward sensation.
• Sufficient upper extremity function to use walking aids (walkers, crutches, canes).
• Poor hip-knee-ankle coordination during swing
• Hip, knee and ankle joint range within normal limits.
• Ability to clearly understand written and oral direction in English to provide consent.
• BMI < 30
• Absence of psychological and cognitive problems or chemical dependency
• No acute orthopedic or medical complications

You may not qualify if…

• Presence of demand pacemakers.
• Edema of the affected limb/s.
• Uncontrolled seizures/epilepsy.
• Severe depression.
• Botulin toxin treatment within 12 months.
• Peripheral neuropathy.
• Respiratory disease.
• Chronic pain.
• Rapidly progressive course suggestive of Marburg variant, Hurst encephalomyelitis or PPMS with three or more system involvement.
• Concurrent treatment with Tysabri.
• Cardiac arrhythmias with associated hemodynamic instability.
• Lower extremity injuries that limit range of motion or function
• Joint problems (hip or leg) that limit range of motion or cause pain with movement
• Women during pregnancy
• Patients with a relapse in the 3 months prior to presentation for study evaluation
• Patients with more than two relapses within the past 12 months

Where it is running

• Louis Stokes VA Medical Center, Cleveland, OH — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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