Comprehensive Assessment of Neurodegeneration and Dementia

Recruiting now

Conditions studied: Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Impairment, Parkinson's Disease (PD), Lewy Body Disease(LBD), Mixed Dementia, Frontotemporal Dementia (FTD), Alzheimer Disease (AD), Cognitively Unimpaired, Subjective Cognitive Decline (SCD)

In brief

This is a longitudinal observational study recruiting individuals between the ages of 50 and 90 with different types of dementia as well as a comparison group without cognitive deficits. Participants are/will be recruited at sites across Canada and will undergo assessments, neuroimaging, and biological sample collection.

Key facts

Study ID

NCT03402919

Run by

McGill University

People needed

1573

Starts

2016-06-01

Expected to finish

2029-12-01

Last updated by the study team

2026-01-20

Who can join

Age: 50 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Has subjective or objective cognitive impairment
• Written informed consent must be obtained and documented (from the patient or, where jurisdictions allow it, from a caregiver/family member)
• Sufficient proficiency in English or French to undertake self report and neuropsychological testing
• Geographic accessibility to the study site
• Must have a study partner who can participate as required in the protocol (provide corroborative information)
• Up to 12 years of education
• Fits into one of the following groups: Cognitively Unimpaired, Subjective Cognitive Impairment, Mild Cognitive Impairment, Vascular Mild Cognitive Impairment, Parkinson's Disease, Parkinson's Disease with Mild Cognitive Impairment

You may not qualify if…

• The presence of other significant known chronic brain disease such as: moderate to severe chronic static leukoencephalopathy (including previous traumatic injury), multiple sclerosis, a serious developmental handicap, malignant tumors, Parkinson's disease (other than for the Parkinson's cohort), and other rarer brain illnesses
• Ongoing alcohol or drug abuse which in the opinion of the investigator may interfere with the subject's ability to comply with the study procedures
• Symptomatic stroke within the previous year
• Unable to undergo MRI scan due to medical contraindications or inability to tolerate the procedure

Where it is running

• Hamilton General Hospital — Hamilton, Ontario, Canada (enrolling)
• Baycrest Clinical Unit — Toronto, Ontario, Canada (enrolling)
• St. Joseph's Health Care London — London, Ontario, Canada (enrolling)
• Gait and Brain Lab — London, Ontario, Canada (enrolling)
• Jewish General Hospital/McGill Memory Clinic — Montreal, Quebec, Canada (enrolling)
• Clinique de cognition Institut universitaire de gériatrie de Montréal — Montreal, Quebec, Canada (enrolling)
• Hôpital Enfant-Jésus — Québec, Quebec, Canada (enrolling)
• University of Calgary — Calgary, Alberta, Canada (enrolling)
• Djavad Mowafaghian Centre for Brain Health — Vancouver, British Columbia, Canada (enrolling)
• University of Alberta Hospital — Edmonton, Alberta, Canada (enrolling)
• Veteran's Memorial Building — Halifax, Nova Scotia, Canada (enrolling)
• Centre de recherche sur le vieillissement CIUSSS de l'Estrie-CHUS — Sherbrooke, Quebec, Canada
• Island Health — Victoria, British Columbia, Canada
• Bruyère Research Institute — Ottawa, Ontario, Canada
• Kawartha Centre — Peterborough, Ontario, Canada
• Sunnybrook Health Sciences Centre — Toronto, Ontario, Canada
• University Health Network Memory Clinic — Toronto, Ontario, Canada
• University of Waterloo — Waterloo, Ontario, Canada
• Research Institute of the McGill University Health Centre — Montreal, Quebec, Canada

Full record on ClinicalTrials.gov

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