Biology of Juvenile Myoclonic Epilepsy
Recruiting now
Conditions studied: Juvenile Myoclonic Epilepsy
In brief
The investigators are collecting genetic information through blood samples as well as clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe and North America. This study will draw on both existing and new samples from JME patients. These will be compared to anonymised data from samples for 2000 controls. The goal of this study is to find the genetic cause of JME. Finding the cause will help create better treatments for JME, as well as improve patient outcomes by allowing us to detect it earlier.
Key facts
- Study ID
- NCT03400371
- Run by
- King's College London
- People needed
- 1000
- Starts
- 2017-07-13
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2025-09-05
Who can join
Age: 10 and older, up to 40. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of Juvenile Myoclonic Epilepsy in accordance with Consensus criteria
- Age of myoclonus onset 10-25 years
- Seizures comprising predominant or exclusive early morning myoclonus of upper extremities
- EEG interictal generalized spikes and/or polyspike and waves with normal background
- Current age 10-40 years
You may not qualify if…
- Myoclonus only associated with carbamazepine or lamotrigine therapy
- EEG showing predominant focal interictal epileptiform discharges or abnormal background
- Any evidence of progressive or symptomatic myoclonus epilepsy or focal seizures
- Global learning disability
- Dysmorphic syndrome
- Unable to provide informed consent
- Regrettably, we are currently unable to accept self-referrals to the BIOJUME study.
Where it is running
- Swansea University — Swansea, United Kingdom (enrolling)
- Royal London Hospital — London, United Kingdom (enrolling)
- St Thomas' Hospital — London, United Kingdom (enrolling)
- King's College Hospital NHS Trust — London, United Kingdom (enrolling)
- Hospital for Sick Kids — Toronto, Ontario, Canada (enrolling)
- Charles University — Prague, Czechia (enrolling)
- Danish National Epilepsy Centre — Dianalund, Denmark (enrolling)
- Tallinn Children's Hospital — Tallinn, Estonia (enrolling)
- University Robert Debré — Paris, France (enrolling)
- Commissione Genetica Lega Italiana contro l'Epilepssia — Roma, Italy (enrolling)
- Vestre Viken Health Trust, Oslo — Drammen, Norway (enrolling)
- Walton Centre for Neurology and Neurosurgery — Liverpool, United Kingdom (enrolling)
- St Luke's Roosevelt Hospital — New York, New York, United States
- Nationwide Children's Hospital — Columbus, Ohio, United States
- Mount Sinai-Beth Israel Medical Center — New York, New York, United States
Full record on ClinicalTrials.gov
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