Trial to Evaluate Efficacy and Safety of Lenabasum in Diffuse Cutaneous Systemic Sclerosis

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Diffuse Cutaneous Systemic Sclerosis

In brief

This is a Phase 3 multicenter, double-blind, randomized, placebo-controlled study assessing the efficacy and safety of lenabasum for the treatment of diffuse cutaneous systemic sclerosis (SSc). Approximately 354 subjects will be enrolled in this study at about 60 sites in North America, Europe, Australia, and Asia. The planned duration of treatment with study drug is 52 weeks.

Key facts

Study ID

NCT03398837

Run by

Corbus Pharmaceuticals Inc.

People needed

365

Starts

2017-12-18

Expected to finish

2020-12-21

Last updated by the study team

2021-03-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Pacific Arthritis Care Center — Los Angeles, California, United States
• UCLA — Los Angeles, California, United States
• Stanford University — Palo Alto, California, United States
• University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States
• Georgetown University Medical Center — Washington D.C., District of Columbia, United States
• Northwestern University — Chicago, Illinois, United States
• Tulane University Medical Center — New Orleans, Louisiana, United States
• John Hopkins University, Scleroderma Center — Baltimore, Maryland, United States
• Massachusetts General Hospital, Division of Rheumatology — Boston, Massachusetts, United States
• Boston University Medical Center (BUMC) - General Clinical Research Unit (GCRU) — Boston, Massachusetts, United States
• Michigan Medicine — Ann Arbor, Michigan, United States
• University of Minnesota Health Clinical Research Unit — Minneapolis, Minnesota, United States
• Dartmouth Hitchcock Medical Center — Lebanon, New Hampshire, United States
• Rutgers Clinical Research Center, Robert Wood Johnson Medical School — New Brunswick, New Jersey, United States
• The Steffens Scleroderma at The Center for Rheumatology — Albany, New York, United States
• Columbia University Medical Center — New York, New York, United States
• Hospital for Special Surgery — New York, New York, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• University of Toledo — Toledo, Ohio, United States
• University of Pennsylvania Health System - PCAM, Dept. of Rheumatology — Philadelphia, Pennsylvania, United States
• UPMC Arthritis and Autoimmunity Center, Falk Clinic — Pittsburgh, Pennsylvania, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• Metroplex Clinical Research Center — Dallas, Texas, United States
• UTP Rheumatology Clinic — Houston, Texas, United States
• University of California San Diego — La Jolla, California, United States

Full record on ClinicalTrials.gov

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