Defining the Temporal Changes in the Acute Phase Response During Graded Exercise: A Prospective Study
Enrolling by invitation · Not applicable
Conditions studied: Acute Phase Response
In brief
The purpose of this study is to detail the precise temporal changes in the APR that occur in response to exercise in order to determine the types of exercise that confer maximal reparative fibrinolysis. Published research and preliminary studies conducted in our lab suggest that different types of exercise will preferentially activate fibrinolysis over coagulation, thereby promoting improved global tissue health \[8\]. As such, measuring markers of the APR in healthy individuals 1) at rest, 2) walking (light intensity exercise), 3) running (moderate intensity exercise), and 4) following endurance running (a marathon) will allow us to establish a baseline for the temporal changes in the APR that avoid activation of the procoagulant survival phase while maximizing the repair phase. Specific aims 1. To measure the acute phase response fibrinolysis, plasminogen consumption, and inflammatory profiles of healthy individuals before and after graded exercise (at rest, light intensity, medium intensity) and after prolonged exercise at medium intensity as defined by changes in fibrinolysis, plasminogen consumption, and inflammatory response. 2. To track the APR through modulated exercise in order to determine the type of exercise that enhances physiologic benefit and limits harm.
Key facts
- Study ID
- NCT03398304
- Run by
- Vanderbilt University Medical Center
- People needed
- 35
- Starts
- 2017-11-29
- Expected to finish
- 2027-04-01
- Last updated by the study team
- 2026-05-15
Who can join
Age: 18 and older, up to 49. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Pre-existing health conditions or injuries that may limit the ability to safely participate in exercise
- Acute disease process such as an infection, broken bone, or asthma attack
- Chronic or recent use (within the last 10 days) of any anticoagulant medication or NSAID
- Pregnant women
- Recent inpatient admission within the last six months
- History of smoking or illicit drug use
- Arm 2: Marathon participation Inclusion criteria
- Healthy individuals (male or female) aged 18-49
- In training to complete a marathon (individuals already planning on running a marathon and training accordingly for it)
- BMI between 18.5 and 30.0
- Exclusion criteria
- Pre-existing health conditions or injuries that may limit the ability to safely participate in exercise
- Acute disease process such as an infection, broken bone, or asthma attack
- Chronic or recent use (within the last 10 days) of any anticoagulant medication or NSAID
- Pregnant women
- Recent inpatient admission within the last six months
- History of smoking or illicit drug use
Where it is running
- Vanderbilt Orthopaedics — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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