Oral vs Intravenous Acetominophen for Postoperative Pain in Minimally Invasive Gynecologic Surgery

Completed · Not applicable

Conditions studied: Post-operative Pain

In brief

Hypothesis: Postoperative pain will be equivalent in patients receiving preemptive oral acetaminophen as compared to patients receiving preemptive intravenous acetaminophen following minimally invasive benign gynecologic surgery. Primary outcome: • Difference in postoperative pain comparing preemptive use of PO versus IV acetaminophen o Mean Visual analog Scale (VAS) scores will be compared between the intervention group (PO acetaminophen) and the control group (IV acetaminophen). Secondary outcomes: * Difference in postoperative analgesic use between groups o Narcotics, NSAIDs * Difference in postoperative N/V between groups o Patient rated measure - none, mild, moderate, severe * Cost comparison between drugs

Key facts

Study ID

NCT03391284

Run by

Scripps Health

People needed

75

Starts

2016-02-01

Expected to finish

2018-02-01

Last updated by the study team

2022-11-22

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients 18 years of age or older scheduled to undergo robotic-assisted laparoscopic hysterectomy for benign conditions.

You may not qualify if…

• Known or suspected malignancy,
• Active liver/renal disease,
• Chronic alcohol use/alcoholism,
• Allergy to acetaminophen,
• Conversion to laparotomy,
• hx gastroparesis,
• Poorly controlled insulin dependent diabetes or gastric bypass surgery,
• Regular/recent (past 6 months) narcotic use,
• Inability to swallow pills.

Where it is running

• Scripps Clinic — San Diego, California, United States
• Scripps Clininc Dept of Ob/Gyn — San Diego, California, United States

Full record on ClinicalTrials.gov

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