Metabolic Profile of Bone in Professional Athletes

Recruiting now

Conditions studied: Bone Disease, Metabolic, Physical Activity

In brief

Physical activity is a key stimulus for bone metabolism through both direct mechanisms (e.g., as a result of the applied load and/or impact) and indirect mechanisms (e.g., the activation of several metabolic pathways and the production of several mediators and effectors that have systemic effects). However, different kinds of physical activity exert different effects on bone and endocrine system. Aim of the study is to investigate the effects of different kinds of physical activity on bone metabolism and on the relationships existing between bone metabolism, energy metabolism, hormone profile, and organ functionality.

Key facts

Study ID

NCT03386981

Run by

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

People needed

200

Starts

2016-02-04

Expected to finish

2027-02-04

Last updated by the study team

2025-09-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• >/= 18 yo
• healthy status
• caucasians

You may not qualify if…

• < 18 yo
• pregnancy status
• ongoing or previous (<5 years) neoplasia
• acute or chronic inflammatory pathologies
• primary metabolic diseases of bone
• recent bone fractures (< 6 months)
• chronic drugs
• recent drugs administration (< 2 months) for non steroidal anti-inflammatory drugs (NSAIDs) and steroids
• anxious-depressive conditions
• inability to understand the information given by the recruiting physician

Where it is running

• Istituto Ortopedico Galeazzi — Milan, Italy (enrolling)

Full record on ClinicalTrials.gov

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