Investigating Bone and Skeletal Muscle Interaction in Men With Prostate Cancer

Completed

Conditions studied: Prostate Cancer

In brief

The overall goal of this pilot project is to test the hypothesis that a decline in muscle strength precedes the decline in bone strength in men undergoing androgen deprivation therapy (ADT) for prostate cancer. The investigators will measure changes in serum biomarkers involved in muscle-bone crosstalk, anatomic changes in muscle and bone structure and strength that could ultimately contribute to fractures. The findings from this research will inform design of interventions to reduce falls and hip fractures in patients undergoing ADT as well as application to broader populations of at risk patients.

Key facts

Study ID

NCT03386812

Run by

University of Texas Southwestern Medical Center

People needed

19

Starts

2017-10-01

Expected to finish

2020-11-29

Last updated by the study team

2021-01-15

Who can join

Age: 55 and older, up to 89. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Dx with prostate cancer and planned ADT therapy

You may not qualify if…

• Contraindication to MRI
• Limited life expectancy
• Inability to participate in exercise testing
• Severe functional impairment
• Chronic kidney disease 4 or worse
• Hgb < 9
• Use of anti-resorptive agent
• non-English speaking
• Bone metastasis

Where it is running

• UT Southwestern — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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