Basket Study to Evaluate the Therapeutic Activity of Simlukafusp Alfa as a Combination Therapy in Participants With Advanced and/or Metastatic Solid Tumors

Stopped early · Phase 2

Conditions studied: Advanced/Metastatic Head and Neck, Oesophageal and Cervical Cancers

In brief

This is an open-label, multicenter, basket trial Phase II study to evaluate the antitumor activity of simlukafusp alfa in combination with atezolizumab in participants with advanced and/or metastatic solid tumors. Currently the focus is on participants with Head and Neck, oesophageal and cervical cancers with confirmed squamous cell carcinoma histology type.

Key facts

Study ID

NCT03386721

Run by

Hoffmann-La Roche

People needed

256

Starts

2018-02-19

Expected to finish

2021-12-30

Last updated by the study team

2023-02-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants who have progressed on at least one previous regimen of anticancer therapy (chemotherapy, mutation targeted therapy, and/or CPI therapy)
• Measurable disease, as defined by RECIST Version 1.1
• Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1 or Karnofsky Performance Score greater than or equal to (>=) 70
• Life expectancy of >=12 weeks
• Confirmed at least one tumor lesion with location accessible to safely biopsy per clinical judgment of the treating physician.
• Biopsies are not applicable to participants in Cohorts G, H, K, and L presenting with a single target lesion and absence of any non-target lesion.
• Consent to provide an archival tumor tissue sample (if available, applicable to all participants)
• Willingness to undergo baseline and on-treatment tumor biopsies for pharmacodynamics (PD) biomarker analysis (biopsies are optional for Cohort A)
• Adequate cardiovascular function as defined in the study protocol
• AEs related to any previous radiotherapy, chemotherapy, or surgical procedure must have resolved to Grade less than or equal to (<=) 1, except alopecia (any grade) and Grade 2 peripheral neuropathy
• Adequate haematological, liver, and renal functions.
• Participants with unilateral pleural effusion (indications other than NSCLC) are eligible if they fulfill both of the following:
• NYHA Class 1
• Forced expiratory volume 1 (FEV1) and forced vital capacity (FVC) >70% of predicted value; participants with lung metastases should present with DLCO >60% of predicted value.
• Participants with Gilbert's syndrome will be eligible for the study
• Participants must have had confirmed diagnosis of recurrent or metastatic squamous cell carcinoma head and neck, or esophageal cancer or metastatic, persistent or recurrent squamous cervical cancer.

You may not qualify if…

• Symptomatic or untreated central nervous system (CNS) metastases
• History of treated asymptomatic CNS metastases as described in the protocol
• Spinal cord compression not definitively treated with surgery and/or radiation or previously diagnosed and treated spinal cord compression without evidence that disease has been clinically stable for >=2 weeks before enrollment
• Leptomeningeal disease
• An active second malignancy
• Penetrating tumor infiltration
• Evidence of significant, uncontrolled concomitant diseases that could affect compliance with the protocol or interpretation of results
• Episode of significant cardiovascular/cerebrovascular acute disease within 6 months before study treatment administration
• History of significant vascular disease (for example, aortic aneurysm, aortic dissection)
• Active or uncontrolled infections
• Human immunodeficiency virus (HIV) or Active Hepatitis A, B, C, D or E infection (HAV/HBV/HCV/HDV/HEV).
• Severe infection within 4 weeks before study treatment administration including, but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia.
• History of chronic liver disease or evidence of hepatic cirrhosis
• Dementia or altered mental status that would prohibit informed consent
• History of, active or suspicion of autoimmune disease
• History of idiopathic pulmonary fibrosis, pneumonitis (including drug-induced), organizing pneumonia (bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or evidence of active pneumonitis on screening chest computed tomography (CT) scan. History of radiation pneumonitis in the radiation field (fibrosis) is permitted
• Bilateral pleural effusion confirmed by X-ray
• Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding that give reasonable suspicion of a disease or condition that would contraindicate the use of an investigational drug
• Concurrent therapy with any other investigational drug
• Immunomodulating agents as described in study protocol
• Chronic use of steroids
• Last dose with any cytostatic treatments < 28 days before study treatment administration
• Radiotherapy within the last 4 weeks before start of study treatment administration, with the exception of limited field palliative radiotherapy
• Administration of a live, attenuated vaccine within 4 weeks before Cycle 1 Day 1 or at any time during the study and 5 months after the last dose of atezolizumab
• Major surgery or significant traumatic injury <28 days before study treatment administration (excluding fine needle biopsies) or if wound healing has not completed after surgery or anticipation of the need for major surgery during study treatment

Where it is running

• University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
• Cancer Treatment Centers of America — Newnan, Georgia, United States
• UZ Antwerpen — Edegem, Belgium
• UZ Gent — Ghent, Belgium
• UZ Leuven Gasthuisberg — Leuven, Belgium
• Institut Bergonie — Bordeaux, France
• Hopital Timone Adultes; Oncologie Medicale Et Usp — Marseille, France
• ICM; Medecine B3 — Montpellier, France
• Gustave Roussy Cancer Campus — Villejuif, France
• Universitätsklinikum Essen; Innere Klinik (Tumorforschung) — Essen, Germany
• Rambam Medical Center; Oncology — Haifa, Israel
• Auckland City Hospital; Clinical Oncology — Auckland, New Zealand
• Uniwersyteckie Centrum Kliniczne; Osrodek Badan Wczesnych Faz — Gda?sk, Poland
• Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie; Oddzial Badan Wczesnych Faz — Warsaw, Poland
• N.N.Burdenko Main Military Clinical Hospital; Oncology Dept — Moscow, Russia
• S-Pb clinical scientific practical center of specialized kinds of medical care (oncological) — Saint Petersburg, Russia
• National University Hospital; National University Cancer Institute, Singapore (NCIS) — Singapore, Singapore
• National Cancer Centre; Medical Oncology — Singapore, Singapore
• Seoul National University Bundang Hospital — Seongnam-si, South Korea
• Severance Hospital, Yonsei University Health System — Seoul, South Korea
• Seoul National University Hospital — Seoul, South Korea
• Asan Medical Center — Seoul, South Korea
• Samsung Medical Center — Seoul, South Korea
• Clinica Universitaria de Navarra — Pamplona, Navarre, Spain
• Hospital del Mar; Servicio de Oncologia — Barcelona, Spain

Full record on ClinicalTrials.gov

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