Studies of Sulfur Metabolism in Humans

Completed · Early Phase 1

Conditions studied: Metabolic Side Effects of Drugs

In brief

The study test whether the NSAID allosteric site of human sulfotransferase 1A1 (SULT1A1) is operative in humans. The study will test the effects of mefenamic acid (MEF) on the sulfonation of acetaminophen (APAP, a SULT1A1 specific substrate) and dehydroepiandrosterone (DHEA, a SULT2A1 substrate). If the allosteric site is active in vivo, MEF is predicted to result in a decrease in sulfonation of APAP (MEF inhibits SULT with high affinity (Ki = 23 nM), and to have no effect on sulfonation of the DHEA (MEF has little or no effect on SULT2A1 activity).

Key facts

Study ID

NCT03383133

Run by

Albert Einstein College of Medicine

People needed

1

Starts

2018-01-11

Expected to finish

2023-02-02

Last updated by the study team

2023-10-27

Who can join

Age: 61 and older, up to 61. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Gender - one male
• Age - 61 y.o.
• Healthy
• Agreed to sign the consent form

You may not qualify if…

• ● None

Where it is running

• Albert Einstein Collage of Medicine — The Bronx, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.