Effect of Beetroot Juice on Blood Pressure Regulation in Post Menopausal Women
Completed · Phase 2 · Has a placebo group
Conditions studied: Postmenopausal Women
In brief
In this study the investigators will test the hypothesis that acute consumption of inorganic nitrate (supplied in concentrated beetroot juice) reduces artery stiffness and resting blood pressure, and lessens the rise in blood pressure during handgrip exercise in postmenopausal women. Understanding and improving artery function and blood pressure regulation in women is important because they undergo accelerated arterial stiffening after menopause and have much larger increases in blood pressure when they exercise compared with either premenopausal women or men of similar age.
Key facts
- Study ID
- NCT03380000
- Run by
- Penn State University
- People needed
- 16
- Starts
- 2014-09-12
- Expected to finish
- 2020-01-01
- Last updated by the study team
- 2022-07-12
Who can join
Age: 55 and older, up to 80. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Resting systolic blood pressure less than or equal to 160 mmHg
- Resting diastolic blood pressure less than or equal to 100 mmHg
You may not qualify if…
- Overt cardiovascular, metabolic, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s)
- Users of any tobacco and/or nicotine products (smokers, chewing tobacco, nicotine-containing patches/gum, smokeless cigarettes)
- Body mass index greater than 35
- Total cholesterol greater than 239 mg/dl
- LDL cholesterol greater than 159 mg/dl
- Fasting blood triglycerides greater than 199 mg/dl
- Fasting blood glucose greater than 109 mg/dl and HbA1c greater than 6.0%
- Individuals currently taking any of the following medications:
- blood pressure lowering medication (e.g., beta blockers, ACE inhibitors, angiotensin antagonists, calcium channel blockers, diuretics)
- lipid-lowering medication (e.g., statins)
- nitrates (e.g. nitroglycerin) for angina
- phosphodiesterase inhibitors (e.g., Viagra)
- anti-inflammatory drugs
- Individuals currently taking hormone replacement therapy
Where it is running
- Penn State University — University Park, Pennsylvania, United States
Full record on ClinicalTrials.gov
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