Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-SA) for Patients With Spinocerebellar Ataxia

Starting soon · Phase 2

Conditions studied: Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3, Spinocerebellar Ataxia Type 6

In brief

The purpose of this study is verify the safety and efficacy of Human Umbilical Cord Mesenchymal Stem Cells (UC-MSC) therapy for patients with Spinocerebellar Ataxia, and in addition, explore the possible mechanisms of UC-MSC therapy in Spinocerebellar Ataxia.

Key facts

Study ID

NCT03378414

Run by

Sclnow Biotechnology Co., Ltd.

People needed

45

Starts

2026-12-31

Expected to finish

2027-12-31

Last updated by the study team

2026-04-23

Who can join

Age: 16 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical and genomic test diagnoses as spinocerebellar ataxias (SCA) (include SCA 1, SCA 2, SCA 3, SCA 6), SARA (Scale for Assessment and Rating of Ataxia) score is 2-5, can complete 8-meter walking test（8MW）
• Do not receive stem cells treatment in 6 months
• Participants sign the consent form based on the experiment process and statement

You may not qualify if…

• Cardiac, renal, hepatic insufficiency; total bilirubin is 1.5 times higher than normal value, aspartate transaminase（AST）or alanine aminotransferase（ALT）is 2.5 times higher than normal value
• Hemogram: total white blood cells <3.0 * 10\^9 cells/L, blood platelet <75 * 10\^9/L, hemoglobin <100g/L
• pneumonia, or severe infection
• With severe allergic history
• Brain organic disorder, like brain tumor
• Serum with HIV, syphilis antibody positive
• Severe mental disease, cognitive disorder patients
• Other severe system or organ organic disease
• Pregnant, breast feeding, or planning pregnant women
• Participate other clinical experiments in 3 months
• With some other conditions that doctor propose not to participate

Full record on ClinicalTrials.gov

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