Histology Post-Endoscopic Eradication Therapy (EET)

Completed

Conditions studied: Esophageal Reflux, Barrett Esophagus

In brief

This study is looking at a cohort of patients who have undergone treatment for Barrett's Esophagus (BE) and who have experienced complete eradication of the disease. The aim of the proposed study is to evaluate the histologic features of the neosquamous epithelium (NSE) following complete eradication of intestinal metaplasia (CE-IM) in patients undergoing routine surveillance biopsies and compare these data to a direct measure of reflux using 24hr pH impedance, to determine the correlation between histology and persistent reflux. These data will allow us to more accurately risk stratify patients for recurrence of BE following EET.

Key facts

Study ID

NCT03375060

Run by

Northwestern University

People needed

65

Starts

2017-08-02

Expected to finish

2017-11-05

Last updated by the study team

2017-12-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• - Patients who have undergone endoscopic eradication therapy and 24hr pH impedance testing as part of standard of care between 2009 and 2014.
• - Individuals who have signed a consent to be part of the Prospective Evaluation of Barrett's Esophagus Study population.

You may not qualify if…

• - Individuals who are not yet adults (infants, children and teenagers), pregnant women and prisoners will be excluded from the study.
• - Patient who were previously unable or unwilling to give consent to the Prospective Evaluation of Barrett's Esophagus Study will be excluded.

Where it is running

• Northwestern University — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.