Gut Microbiota of Preterm Infants and Full-term Infants at Early Life
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Conditions studied: Preterm Infant, Gut Microbiome
In brief
The aim of this study is to obtain a longitudinal view of the gut microbial establishment of a cohort of 51 preterm (PT) infants compared to 50 full-term (FT) infants from birth to 90 days of age, and to identify key clinical factors that affect the establishment of neonatal microbiome. The hypothesis of the investigators is that the gut microbiota progression of PT group and FT group is different in diversity and composition. Antibiotics and its usage duration is likely the main factor disturbing the colonization and development of the gut microbiome of PT infants.
Key facts
- Study ID
- NCT03373721
- Run by
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- People needed
- 102
- Starts
- 2014-07-20
- Expected to finish
- 2028-12-20
- Last updated by the study team
- 2024-04-17
Who can join
Age: 0 and older, up to 0. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Preterm infants
- gestational age <37 weeks;
- no gastrointestinal tract disorders, metabolic diseases, or viral hepatitis;
- hospital stay > 7 days;
You may not qualify if…
- NICU stay less than 7 days
- Necrotizing enterocolitis infant
- Control group:
- Full-term healthy infants;
- gestational age >37 weeks;
- vaginally born;
- no gastrointestinal tract disorders, metabolic diseases, or viral hepatitis.
Where it is running
- Department of NICU, XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine — Shanghai, China (enrolling)
Full record on ClinicalTrials.gov
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