Targeting Self-regulatory Deficits Through Cognitive Remediation Intervention
Completed · Not applicable
Conditions studied: Drug Use Disorders
In brief
We are proposing a small randomized clinical trial in which 100 substance users will complete the existing Psychotherapy Development Center (PDC) pretreatment assessment battery as well as a novel battery of assays to evaluate cognitive-affective functioning. After completing pretreatment assessments, participants will be randomized to either a (1) cognitive remediation program (training tasks) specifically designed to address cognitive-affective dysregulation or (2) control tasks (verbal fluency tasks). Tasks will be completed twice per week for 4 weeks, after which assessment batteries will be repeated. Finally, we will evaluate real-world behavior and the durability of the training via a one-month follow-up, which will include assessment of substance use as well as the cognitive-affective battery.
Key facts
- Study ID
- NCT03373240
- Run by
- Yale University
- People needed
- 46
- Starts
- 2018-01-22
- Expected to finish
- 2019-10-17
- Last updated by the study team
- 2021-01-08
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Meet current DSM-5 criteria for an alcohol, stimulant, cannabis, or opioid use disorder.
- Are sufficiently stable for 4 weeks of outpatient treatment.
- Are willing to provide locator information.
- Are fluent in English and have a 4th grader or higher reading level
You may not qualify if…
- Meet DSM-5 criteria for a bipolar or schizophrenic disorder.
- Who have a legal case pending such that incarceration during the 4-week protocol is likely.
- Are physically dependent on alcohol, opioids or benzodiazepines or who report recent PCP use.
- Have a baseline Shipley estimated IQ less than 70
- Have 3 or more head injuries with loss of consciousness for over 30 minutes or lasting effects
- Have a history of chronic illness or neurological disorders (e.g., epilepsy or stroke) that would complicate evaluation of effects of cognitive training
Where it is running
- Substance Abuse Treatment Center (SATU) — New Haven, Connecticut, United States
Full record on ClinicalTrials.gov
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