Pegzilarginase and Pembrolizumab for Extensive Disease Small Cell Lung Cancer
Completed · Phase 1/Phase 2
Conditions studied: Small-cell Lung Cancer
In brief
The main purpose of this Phase 1/2 study is to determine the safety and efficacy of pegzilarginase in combination with pembrolizumab in patients with ED-SCLC who have relapsed or progressive disease on or within 6 months of platinum-based chemotherapy.
Key facts
- Study ID
- NCT03371979
- Run by
- Aeglea Biotherapeutics
- People needed
- 68
- Starts
- 2017-12-21
- Expected to finish
- 2021-01-01
- Last updated by the study team
- 2021-11-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama, Mitchell Cancer Institute — Mobile, Alabama, United States
- University of Colorado — Aurora, Colorado, United States
- Rocky Mountain Cancer Centers — Denver, Colorado, United States
- Mid Florida Hematology and Oncology Centers — Orange City, Florida, United States
- Woodlands Medical Specialists, PA — Pensacola, Florida, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- Emory University — Atlanta, Georgia, United States
- University of Michigan — Ann Arbor, Michigan, United States
- Karmanos Cancer Institute — Detroit, Michigan, United States
- Washington University — St Louis, Missouri, United States
- Nebraska Cancer Specialists — Omaha, Nebraska, United States
- The Valley Hospital, Luckow Pavilion — Paramus, New Jersey, United States
- Oncology Hematology Care Inc. — Cincinnati, Ohio, United States
- Providence Cancer Center — Portland, Oregon, United States
- UPMC Cancer Center — Pittsburgh, Pennsylvania, United States
- Charleston Hematology Oncology Associates — Charleston, South Carolina, United States
- West Clinic — Germantown, Tennessee, United States
- Sarah Cannon Research Institute — Nashville, Tennessee, United States
- Texas Oncology-Memorial City — Houston, Texas, United States
- Texas Oncology-Tyler — Tyler, Texas, United States
- Oncology & Hematology Associates of SW Virginia — Blacksburg, Virginia, United States
- Fundacion De Investigacion, Hematology/Oncology — San Juan, Puerto Rico
Full record on ClinicalTrials.gov
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