Engineered Immune Effectors Against Cervical Cancer

Recruiting now · Phase 1/Phase 2

Conditions studied: Cervical Cancer

In brief

The primary objective of this study is to evaluate the safety of cervical cancer specific engineered immune effectors (CC-EIEs). The secondary objectives are to evaluate the rate of successful CC-EIE generation in vitro and determine the anti-CC efficacy.

Key facts

Study ID

NCT03362619

Run by

Shenzhen Geno-Immune Medical Institute

People needed

20

Starts

2026-06-01

Expected to finish

2030-12-31

Last updated by the study team

2026-06-23

Who can join

Age: 10 and older, up to 80. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Written, informed consent obtained prior to any study-specific procedures.
• Age older than 10 years.
• Eastern Cooperative Oncology Group (ECOG) PS of 0 or 1.
• Expected survival ≥ 12 weeks.
• Not pregnant, and on appropriate birth control if of childbearing potential.
• Evidence of high-risk HPV infection.
• Stage III-IV or recurrent cervical cancer.
• Initial hematopoietic reconstitution with
• neutrophils (ANC) ≥ 1,000/mm\^3;
• platelet (PLT) ≥ 100,000/mm\^3.
• Proper renal and hepatic functions (ULN denotes "upper limit of normal range") with
• serum creatinine ≤ 2×ULN;
• serum bilirubin ≤ 2×ULN;
• AST/ALT ≤ 2×ULN;
• ALKP ≤ 5×ULN;
• serum bilirubin. 2.0 is acceptable in the setting of known Gilbert's syndrome.
• Human immunodeficiency virus (HIV) and Hepatitis C virus (HCV) test negative.

You may not qualify if…

• Patients with
• cervical benign lesions: cervical columnar epithelium ectopic, cervical polyps, cervical endometriosis and cervical tuberculous ulcers;
• cervical benign tumors: cervical submucous myoma, cervical cancer, cervical papilloma.
• Patients with evidence of abdominal free air not explained by paracentesis or recent surgical procedure (prior, current or planned treatment).
• Previous exposure to mouse SCC antibody.
• Current or recent treatment (within the 28-day period prior to Day 0) with another investigational drug or previous participation in this study.
• Minor surgical procedures within 2 days prior to Day 0 (including central venous access device placement for chemotherapy administration, tumor biopsies, needle aspirations).
• Pregnant or lactating females.
• Inadequate bone marrow function with
• absolute neutrophil count < 1,000/mm\^3;
• platelet count < 100,000/mm\^3;
• Hb < 9 g/dL.
• Inadequate liver and renal function with
• serum (total) bilirubin > 1.5 x ULN;
• AST \& ALT > 2.5 x ULN (> 5 x ULN in patients with liver metastases);
• alkaline phosphatase > 2.5 x ULN;
• serum creatinine >2.0 mg/dl (> 177 μmol/L);
• urine dipstick for protein uria should be < 2+. Patients with ≥ 2+ proteinuria on dipstick urinalysis at baseline should undergo 24 hour urine collection and must demonstrate < 1 g of protein/24 hr.
• Serious active infection requiring i.v. antibiotics at during screening.
• Subject actively infected with HCV (HCV antibody positive), HBV (HBsAg positive), HIV (HIV antibody positive), HTLV (HTLV antibody positive), Treponema pallidum antibody positive or TB culture positive.

Where it is running

• Shenzhen Geno-immune Medical Institute — Shenzhen, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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