ZIMURA in Combination With LUCENTIS in Patients With Neovascular Age Related Macular Degeneration (NVAMD)

Completed · Phase 2

Conditions studied: Neovascular Age-related Macular Degeneration

In brief

To assess the safety of intravitreal Zimura™ (complement factor C5 inhibitor) administered in combination with Lucentis® 0.5 mg in treatment naïve subjects with neovascular age related macular degeneration (NVAMD)

Key facts

Study ID

NCT03362190

Run by

Ophthotech Corporation

People needed

64

Starts

2017-10-11

Expected to finish

2018-10-18

Last updated by the study team

2025-06-10

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Active subfoveal NVAMD

You may not qualify if…

• History or evidence of severe cardiac disease
• Any major surgical procedure within one month of trial entry
• Subjects with a clinically significant laboratory value
• Any treatment with an investigational agent in the past 60 days for any condition
• Women who are pregnant or nursing
• Known serious allergies to the fluorescein dye used in angiography, povidone iodine, to the components of the ranibizumab formulation, or to the components of the Zimura formulation
• Any prior treatment for AMD other than oral supplements of vitamins and minerals

Where it is running

• Retinal Research Institute — Phoenix, Arizona, United States
• Retina Centers PC — Tucson, Arizona, United States
• Retina Associates SW, PC — Tucson, Arizona, United States
• Retina-Vitreous Associates Medical Group — Beverly Hills, California, United States
• Retina Consultants of Orange County — Fullerton, California, United States
• Retina Consultants of Southern California — Redlands, California, United States
• Retinal Consultants Medical Group — Sacramento, California, United States
• Orange County Retina Medical Group — Santa Ana, California, United States
• Colorado Retina Associates — Golden, Colorado, United States
• Florida Eye Clinic — Altamonte Springs, Florida, United States
• Florida Eye Associates — Melbourne, Florida, United States
• Illinois Eye Center — Peoria, Illinois, United States
• Vitreo Retinal Consultants & Surgeons — Wichita, Kansas, United States
• Ophthalmic Consultants of Boston — Boston, Massachusetts, United States
• VitreoRetinal Surgery — Minneapolis, Minnesota, United States
• Retina Consultants of Nevada — Henderson, Nevada, United States
• Sierra Eye Associates — Reno, Nevada, United States
• Retina Vitreous Surgeons of CNY, PC — Syracuse, New York, United States
• Retina Northwest PC — Portland, Oregon, United States
• Mid Atlantic Retina — Philadelphia, Pennsylvania, United States
• Charleston Neuroscience Institute — Ladson, South Carolina, United States
• Retina Research Institute of Texas — Abilene, Texas, United States
• Strategic Clinical Research Group — Willow Park, Texas, United States
• Peterfy Sandor utcai Korhaz-Rendelointezet es Baleseti Kozpont — Budapest, Hungary
• Budapest Retina Associates — Budapest, Hungary

Full record on ClinicalTrials.gov

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