Treatment of Mild Cognitive Impairment With Transcutaneous Vagal Nerve Stimulation
Completed · Not applicable · Has a placebo group
Conditions studied: Mild Cognitive Impairment
In brief
Patients with amnestic mild cognitive impairment (MCI) often have compromised quality of life (QOL). Cognitive impairment is a major contributor to decrements in QOL and progression of MCI often leads to loss of independence and withdrawal from social participation. MCI, in many patients, is an early expression of neurodegenerative disease. Patients with MCI frequently convert to Alzheimer's disease (AD) (12-16 percent by some estimates per year). Treatments for MCI are of limited scope and availability and of limited effectiveness. Thus, there is great need for treatments that can improve cognition and extend QOL in patients with MCI. The investigators propose to investigate the effect of a non-invasive and safe intervention that should have direct influence on brain systems underlying AD, transcutaneous vagal nerve stimulation (tVNS).
Key facts
- Study ID
- NCT03359902
- Run by
- University of Florida
- People needed
- 59
- Starts
- 2018-01-01
- Expected to finish
- 2022-05-31
- Last updated by the study team
- 2023-10-24
Who can join
Age: 60 and older, up to 89. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Diagnosed with amnestic mild cognitive impairment/mild Alzheimer's disease
- Preservation of independence in functional abilities
- Healthy aged adults without MCI to serve as control group
You may not qualify if…
- Other medical or neurological conditions that may be associated with significant impaired cognition (e..g, moderate to severe traumatic brain injury, epilepsy, etc...)
- Vascular dementia or other non-AD spectrum diagnosed neurodegenerative disorders
- Significant current depression
- Uncorrected vision/hearing loss
- Unable to undergo MRI exam
Where it is running
- Malcom Randall VA Medical Center — Gainesville, Florida, United States
- McKnight Brain Institute — Gainesville, Florida, United States
- University of Florida — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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