Transcutaneous Submandibular Gland Biopsy: Feasibility of Repeat Biopsy as a Progression Marker for Parkinson's Disease

Completed · Not applicable

Conditions studied: Parkinson Disease

In brief

The purpose of this study is to perform biopsies of one of the glands that make saliva. The biopsied tissue will then be analyzed to see if it has changes that occur in Parkinson's disease. This study will determine whether it is possible to do a second biopsy a few years after a previous biopsy and determine whether there are changes in the biopsy that would allow for analysis of disease progression.

Key facts

Study ID

NCT03359226

Run by

Mayo Clinic

People needed

7

Starts

2017-11-21

Expected to finish

2018-05-31

Last updated by the study team

2018-11-06

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• PD patients ages up to age 85.
• Previous participation in a SMG biopsy study at Mayo Clinic Arizona with a positive biopsy being reported

You may not qualify if…

• Evidence for dementia that would preclude the patient from signing informed consent
• History of bleeding diathesis or hematologic disorders
• Medically unable to undergo a core needle biopsy of the submandibular gland
• Prior treatment of the submandibular gland with botulinum toxin injections.
• History of past or current acute infection or abscess of the submandibular gland.
• History of past or current neoplastic process within the submandibular gland.
• History of peripheral neuropathy.

Where it is running

• Mayo Clinic in Arizona — Scottsdale, Arizona, United States

Full record on ClinicalTrials.gov

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