Metallosis on Tissues and Serum Metal Levels in Children

Enrolling by invitation

Conditions studied: Orthopedic Disorder, Retained Metal Implant

In brief

Slightly elevated blood metal levels have been found in adults undergoing hip and knee replacement. It is unknown whether pediatric patients with metal implant(plates/screws/rods) have elevated blood metal levels. This may have an impact on practice if children have high blood metal levels with routine orthopedic implants. If researchers find elevated metal levels, they may recommend patients to have the plates removed or may switch to a different type of metal. Further work on this topic is needed.

Key facts

Study ID

NCT03359109

Run by

Mayo Clinic

People needed

50

Starts

2017-12-01

Expected to finish

2026-09-01

Last updated by the study team

2025-11-04

Who can join

Age: 4 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 4 years - 18 years
• Stainless steel, titanium or titanium-alloy based implants, scheduled for surgery
• De novo surgery where titanium implant placement

You may not qualify if…

• Concomitant infection

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States
• Sanford Health — Sioux Falls, South Dakota, United States

Full record on ClinicalTrials.gov

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