Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)

Recruiting now

Conditions studied: Conjunctival Diseases, Dry Eye Syndromes

In brief

Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of these cell surface markers before and after initiation of a treatment.

Key facts

Study ID

NCT03358979

Run by

Fondation Ophtalmologique Adolphe de Rothschild

People needed

100

Starts

2017-12-14

Expected to finish

2027-03-01

Last updated by the study team

2025-12-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years and over
• Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes
• Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced
• Exclusion criteria - Known pregnancy or breastfeeding
• Control subjects:
• Inclusion criteria
• 18 years and over

You may not qualify if…

• Wearer of contact lenses
• Topical ocular treatment
• Known pregnancy or breastfeeding

Where it is running

• Fondation Ophtalmologique A de Rothschild — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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