Genetic Susceptibility to Listeriosis
Recruiting now · Not applicable
Conditions studied: Listeriosis
In brief
Listeriosis is a rare, severe foodborne infection, responsible for severe invasive infections. It occurs in the great majority of cases in elderly patients and / or patients with comorbidities, with a deficit of innate or cellular immunity. Pregnancy is also a risk factor. The Multicentric Observational NAtional Analysis of Listeriosis and Listeria (MONALISA) is an ongoing national case-control prospective study on listeriosis implemented since 2009 to study risk and prognosis factors for listeriosis. In this cohort, which enrolled 902 patients on 1 August 2014, 7% of patients with neurolisteriosis are under 40 years of age and have no identified risk factor. Genetic susceptibility is suspected in these patients. Genetic susceptibility could also explain the inconstant development of a neurolisteriosis or fetal infection, as well as the particular severity of some infections (death, foetal loss, neurological sequelae). The aim of the study is to identify genetic susceptibility to Listeriosis.
Key facts
- Study ID
- NCT03357536
- Run by
- Institut Pasteur
- People needed
- 100
- Starts
- 2017-11-28
- Expected to finish
- 2027-11-30
- Last updated by the study team
- 2025-09-19
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
Where it is running
- Centre Médical de l'Institut Pasteur — Paris, France (enrolling)
Full record on ClinicalTrials.gov
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