Gelatin, Collagen, Gummy and PINP
Completed · Not applicable
Conditions studied: Collagen Synthesis
In brief
Previous work has shown that gelatin supplementation could increase collagen synthesis in humans. In this study subjects consume placebo, 5 or 15 g of gelatin with a standard amount of vitamin C (48 mg) 1 hour before 6 minutes of jump rope exercise. The feeding and exercise intervention was repeated every 6 hours while the subjects were awake for three days and the amount of the amino terminal procollagen I peptide (PINP) was determined; a marker of collagen synthesis, in the blood. Consistent with the hypothesis that gelatin increases collagen synthesis in humans; the amount of PINP in the 15 g gelatin group was significantly higher than either the placebo or the 5 g groups. These data conclusively demonstrate that gelatin supplementation can increase exercise-induced collagen synthesis in humans. Hydrolyzed collagen has a similar amino acid profile, in particular with high concentrations of glycine, proline, hydroxyproline, and arginine. Thus, the current study aims to determine is the same dose of gelatin, hydrolyzed collagen and a gelatin/collagen mix, all with a standard dose of vitamin C effect PINP levels similarly.
Key facts
- Study ID
- NCT03357432
- Run by
- University of California, Davis
- People needed
- 11
- Starts
- 2017-10-21
- Expected to finish
- 2018-09-07
- Last updated by the study team
- 2018-11-09
Who can join
Age: 18 and older, up to 50. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- Recreationally active male athletes between the ages of 18-50 years of age training 5-6 days per week including at least 1 training session of running per week.
You may not qualify if…
- Receiving any medication that may interfere with the study.
- History of more than 3 musculoskeletal injuries within the past 12 months.
- Health or dietary restriction that would be affected by the supplementation protocol.
- The initial phases of this study will be performed in males since collagen synthesis varies significantly throughout the menstrual cycle in females. Since collagen is the main outcome measure for this study this natural variation would confound the initial phase of the work. Provided this work proves successful then we will aim to process with similar research in females.
Where it is running
- Biological Sciences — Davis, California, United States
Full record on ClinicalTrials.gov
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