Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell Transplantation

Recruiting now · Not applicable

Conditions studied: Allogeneic Hematopoietic Stem Cell Transplantation

In brief

The study concerns donors and patients receiving allogeneic stem cell haematopoietic transplantation. The aim of the study is to analyse HSC graft content in immune effector T (naive, memory, activated, exhausted) and immunoregulatory cell subtypes (Tregs, iNKT, MDSC) and correlate the results with post-transplant immune reconstitution of those different cell subtypes and clinical events (graft-versus-host-disease, relapse, infections). An ancillary study will focus on the impact of microbiota dysbiosis on post-transplant immune response and regulatory cell subsets.

Key facts

Study ID

NCT03357172

Run by

Central Hospital, Nancy, France

People needed

700

Starts

2019-10-01

Expected to finish

2026-09-30

Last updated by the study team

2019-10-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patient of the Nancy CHRU, for whom a CSH allograft is planned. or
• hematopoietic stem cell donors received at Nancy's CHRU for the duration of the research

You may not qualify if…

• Positive HIV
• active hepatitis B or C infection

Where it is running

• CHRU de Nancy — Vandœuvre-lès-Nancy, France (enrolling)

Full record on ClinicalTrials.gov

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