Impact of Transjugular Intrahepatic Portosystemic Shunts on Liver Stiffness

Stopped early · Not applicable

Conditions studied: Portal Hypertension, Liver Fibroses

In brief

Pilot study examining changes in liver stiffness measured by ultrasound before and after TIPS creation

Key facts

Study ID

NCT03352882

Run by

University of Pennsylvania

People needed

1

Starts

2016-08-01

Expected to finish

2019-04-03

Last updated by the study team

2019-10-01

Who can join

Age: 18 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Symptomatic portal hypertension secondary to cirrhosis undergoing elective outpatient TIPS
• Age >18, Age <80
• Capable of giving informed consent

You may not qualify if…

• Coagulopathy defined as international normalized ration (INR) >2 which cannot be corrected with fresh frozen plasma
• Platelet count <50,000/microliter, which cannot be corrected with platelet transfusion
• BMI >35 and/or cirrhosis due to non-alcoholic steatohepatitis (due to inaccurate elastography measurements in patients with fatty liver)
• Urgent or emergent TIPS for bleeding
• Portal vein thrombosis with in the main, 1st, or 2nd order branches of the portal vein
• Hepatic vein thrombosis (ie no Budd Chiari syndrome)
• Excessive alcohol use defined as more than 2 oz in 24 hours on any individual day within the last 30 days
• Inability to provide informed consent
• Pregnant or nursing women
• Enrollment in concurrent therapeutic trial for symptomatic portal hypertension

Where it is running

• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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