Spatial Neglect and Delirium After Stroke
Completed
Conditions studied: Stroke, Delirium, Spatial Neglect
In brief
The goal of this study is to understand what brain mechanisms become disrupted when stroke survivors experience delirium. Delirium is an acute reduction in attention and cognition, associated with poor recovery, longer hospitalization and even death. One major factor increasing the risk of delirium after stroke may be spatial neglect occurring after stroke on the right side of the brain. Spatial neglect affects awareness, orientation, and movement. The study will test the hypothesis that the right-dominant brain networks for arousal and attention are affected in both of these disorders. It is expected that the activity and structural integrity of these brain networks will correlate with behavioral signs and severity of delirium and spatial neglect. To test this hypothesis, the study will measure spatial neglect and delirium symptoms in 45 acute (NYC Health + Hospitals/Bellevue ) and 30 subacute (Kessler Institute for Rehabilitation) stroke survivors and evaluate brain scans for these participants. This study may contribute to knowledge about brain bio-markers of delirium, which will greatly aid in delirium detection in stroke and other disorders.
Key facts
- Study ID
- NCT03349411
- Run by
- Kessler Foundation
- People needed
- 45
- Starts
- 2017-07-18
- Expected to finish
- 2020-12-30
- Last updated by the study team
- 2021-04-30
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Able to give informed consent prior to beginning of testing; have 1st ever ischemic stroke on the right side of the brain; speaks English; >18 years of age
You may not qualify if…
- all of the following will be excluded:
- Participants with another brain disorder expected to produce severe visual-spatial abnormalities (including malignant brain tumor, traumatic brain injury with post-injury neurological problems, or Alzheimer's Disease)
- Women knowing themselves to be pregnant will not be enrolled; pregnancy may itself affect visual-spatial attention. However, women of childbearing potential will not be tested for pregnancy before participating.
- Persons consuming more than 10 alcoholic beverages weekly
- For participants who will undergo an MRI scan the following will be excluded:
- Pacemaker or other implanted electrical device incompatible with the MR environment
- Eye injury to the eye involving metal filings
- Unable to undergo MRI due to doctor recommendation
- Claustrophobia
Where it is running
- Kessler Foundation — West Orange, New Jersey, United States
- NYC Health + Hospitals/Bellevue — New York, New York, United States
Full record on ClinicalTrials.gov
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