rTMS Response Trajectories in Depression

Recruiting now · Not applicable

Conditions studied: Depression

In brief

Notwithstanding the cumulative evidence on the safety and efficacy of transcranial magnetic stimulation in depression care, the non-response rate to transcranial magnetic stimulation (TMS) amongst treatment-resistant depression has remained substantial despite the health care cost and time incurred. There remains a compelling clinical need to find valid biomarkers to inform personalized treatment. Using supervised machine learning on 4 combined features of neuroimaging markers, our group recently reported excellent prediction for clinical response in 70 patients receiving TMS to left dorsolateral prefrontal cortex for medication-resistant major depression in 2015-18 (Phase 1 study).The clinical utility of these potential neuroimaging biomarkers is still uncertain without further validation of the trained model in an independent clinical cohort.

Key facts

Study ID

NCT03348761

Run by

Chinese University of Hong Kong

People needed

70

Starts

2015-08-04

Expected to finish

2026-12-01

Last updated by the study team

2024-02-12

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• right-handed
• meet the Diagnostic and Statistical Manual of Mental Disorder, Fourth Edition (DSM-IV) criteria for major depressive disorder
• at least moderate episode or with a score of >20 on Montgomery-asberg Depression Rating Scale (MADRS) and >18 on Hamilton Depression Rating Scale(HDRS) 17-item;
• has failed to respond adequately to at least one full course (>6 weeks) of antidepressant medication or medication intolerant.

You may not qualify if…

• significant head trauma
• active abuse of alcohol or illegal substances
• current psychotic symptoms
• suicide ideation/recent suicide attempts
• other DSM-IV Axis I and II psychiatric diagnosis
• neurological disorders and contraindications to fMRI (e.g. pace makers, metal implants, pregnancy) or rTMS, or having undergone electroconvulsive therapy in the preceding year.

Where it is running

• Department of Psychiatry, CUHK — Hong Kong, Hong Kong (enrolling)

Full record on ClinicalTrials.gov

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